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A spirohydantoin derivative of dimethoxytetrahydronaphthalene: an experimental anticonvulsant
Neurochemical Research
|April 1, 1984
Abstract:
A 2-spirohydantoin of 6,7-dimethoxytetrahydronaphthalene was synthesized and purified. The compound, showing structural similarities to both phenytoin and dopamine, was found to decrease spontaneous motor activity of mice and to exert a pronounced protective effect against convulsive seizures induced by pentylenetetrazol (Metrazol).