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DSIP reduces amphetamine-induced hyperthermia in mice.

M V Graf, A J Kastin, D H Coy

    Physiology & Behavior
    |August 1, 1984
    PubMed
    Summary

    Delta sleep-inducing peptide (DSIP) shows complex effects on thermoregulation. While DSIP reduced amphetamine-induced hyperthermia in mice at specific doses, results varied across species and analogs, indicating intricate dose-response relationships.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Physiology

    Background:

    • Delta sleep-inducing peptide (DSIP) is known for sleep induction.
    • Previous studies suggest DSIP influences locomotor activity, stress, and thermoregulation.
    • DSIP has been reported to counteract amphetamine-induced hyperthermia in rats.

    Purpose of the Study:

    • To investigate the thermoregulatory effects of DSIP in mice.
    • To examine dose-dependent effects of DSIP and its analogs (D-Ala4-DSIP, DSIP-P) on amphetamine-induced hyperthermia.
    • To compare DSIP's effects in mice and rats.

    Main Methods:

    • Administration of varying concentrations of DSIP, D-Ala4-DSIP, and DSIP-P to mice.
    • Induction of hyperthermia using d-amphetamine (15 mg/kg and 30 mg/kg).

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  • Monitoring and analysis of body temperature changes in response to DSIP treatments.

    • Main Results:

    • DSIP significantly reduced amphetamine-induced hyperthermia in mice at 0.1 and 150 nmol/kg doses, but not other concentrations or in rats.
    • D-Ala4-DSIP demonstrated a bell-shaped dose-response curve, decreasing temperature rise between 50-150 nmol/kg.
    • DSIP-P showed no significant effect on temperature; DSIP did not counteract higher amphetamine doses (30 mg/kg).

    Conclusions:

    • Complex, non-linear dose-effect relationships exist for DSIP and its analogs in modulating thermoregulation.
    • Species-specific differences in DSIP's thermoregulatory effects may be present (mice vs. rats).
    • Further research is needed to fully elucidate the mechanisms underlying DSIP's role in temperature regulation.