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Protein C level at birth.

B Polack, P Pouzol, J Amiral

Thrombosis and Haemostasis

|October 31, 1984

Summary

This summary is machine-generated.

Newborns have significantly lower protein C levels, about one-third of adults, likely due to immature liver function. Abnormal protein C forms were not detected in healthy newborns, unlike in vitamin K deficiency cases.

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Area of Science:

Biochemistry
Neonatal Medicine
Hematology

Background:

Protein C is a crucial vitamin-K-dependent anticoagulant protein.
Neonatal hemostasis differs from adult hemostasis, with lower levels of certain coagulation factors.
Understanding protein C levels in newborns is vital for assessing thrombotic risk.

Purpose of the Study:

To quantify protein C levels in healthy term newborns.
To investigate the relationship between protein C and prothrombin antigen levels at birth.
To explore the presence of abnormal protein C forms in neonatal cord blood.

Main Methods:

Electro-immuno assay with monospecific antiserum was used to measure protein C antigen.
Prothrombin antigen levels were also assessed for correlation.

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Two-dimensional immuno-electrophoresis was employed to detect subcarboxylated protein C forms.

Main Results:

Mean protein C antigen levels in newborns were approximately one-third of adult levels.
A strong correlation was observed between protein C and prothrombin related antigen levels.
Subcarboxylated forms of protein C were not detectable in healthy newborns' cord blood.

Conclusions:

The reduced levels of protein C and prothrombin in newborns are likely attributed to partial hepatic immaturity at birth.
Unlike in neonatal vitamin K deficiency, abnormal protein C forms are not typically found in healthy neonates.
These findings highlight developmental differences in vitamin-K-dependent protein synthesis.