Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacokinetic-pharmacodynamic modelling and simulation using the electrical circuit simulation program SPICE2.

K M Thakker

    Biopharmaceutics & Drug Disposition
    |October 1, 1984
    PubMed
    Summary

    This study introduces SPICE2, a powerful simulation tool for pharmacokinetic-pharmacodynamic (PK-PD) models. SPICE2 leverages network thermodynamics for efficient digital computer simulations, offering advantages in research and education.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparative bioavailability and steady state fluctuations of Tegretol commercial and carbamazepine OROS tablets in adult and pediatric epileptic patients.

    Biopharmaceutics & drug disposition·1992
    Same author

    Effect of food and relative bioavailability following single doses of diclofenac 150 mg hydrogel bead (HGB) capsules in healthy humans.

    Biopharmaceutics & drug disposition·1992
    Same author

    Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations.

    Pharmaceutical research·1991
    Same author

    Dosage form and formulation effects on the bioavailability of vitamin E, riboflavin, and vitamin B-6 from multivitamin preparations.

    The American journal of clinical nutrition·1987
    Same author

    Cost containment using cysteine HCl acidification to increase calcium/phosphate solubility in hyperalimentation solutions.

    JPEN. Journal of parenteral and enteral nutrition·1986
    Same author

    Bacterial endotoxin retention by inline intravenous filters.

    American journal of hospital pharmacy·1986

    Area of Science:

    • Pharmacokinetics and Pharmacodynamics
    • Computational Biology
    • Network Thermodynamics

    Background:

    • Pharmacokinetic-pharmacodynamic (PK-PD) models are crucial for understanding drug behavior in the body.
    • Digital computer simulations offer a powerful approach to analyzing complex PK-PD systems.
    • Existing simulation tools may lack user-friendliness or versatility.

    Purpose of the Study:

    • To describe the application of the SPICE2 electrical circuit simulation program for PK-PD modeling.
    • To highlight the advantages of SPICE2 for both linear and non-linear PK-PD simulations.
    • To demonstrate the utility of SPICE2 in research and education.

    Main Methods:

    • Utilized SPICE2, an electrical circuit simulation program based on network thermodynamics.

    Related Experiment Videos

  • Applied principles of network thermodynamics, relating chemical kinetics and mass transport to electrical circuit laws.
  • Developed detailed program inputs, formats, and options for simulating PK-PD systems.

    • Main Results:

    • Successfully simulated linear and non-linear PK-PD models using SPICE2.
    • Demonstrated the program's capability for single and multiple dose simulations, including accumulation.
    • Illustrated the analogy between Fick's law of diffusion and Ohm's law.

    Conclusions:

    • SPICE2 is a versatile, user-friendly, and powerful tool for PK-PD simulations.
    • The program offers significant advantages in terms of operational ease and efficiency.
    • SPICE2 serves as a valuable educational resource for teaching PK-PD concepts and a practical tool for research.