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Electrocardiographic changes in multi bacillary leprosy.

S Agarwal, S K Aggarwal

Indian Journal of Leprosy

|July 1, 1984

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This study investigated biochemical and ECG changes in 14 multi bacillary leprosy patients. Some patients showed elevated serum cholesterol and SGOT, alongside specific electrocardiogram abnormalities like ST depression and prolonged Q-Tc intervals.

Area of Science:

Medical research
Cardiology
Dermatology

Background:

Leprosy, particularly multi bacillary forms (borderline lepromatous and lepromatous leprosy), can affect various organ systems.
Cardiac involvement in leprosy is not fully understood, necessitating further investigation.

Purpose of the Study:

To investigate biochemical and electrocardiogram (ECG) changes in patients with multi bacillary leprosy.
To identify potential cardiac manifestations associated with this leprosy subtype.

Main Methods:

Biochemical analysis of serum cholesterol and SGOT (Serum Glutamic Oxaloacetic Transaminase).
Electrocardiogram (ECG) recordings were performed on 14 multi bacillary leprosy patients.
Analysis of ECG parameters including P wave, PR interval, QRS complex, ST segment, T wave, and Q-Tc interval.

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Main Results:

Elevated serum cholesterol was observed in 4 out of 14 cases.
Elevated SGOT was found in 2 out of 14 cases.
ECG findings included ST segment depression (2 cases), flat T wave (2 cases), inverted T wave (1 case), and prolonged Q-Tc interval (3 cases). No significant changes were noted in P wave, PR interval, or QRS complex.

Conclusions:

Multi bacillary leprosy can be associated with biochemical abnormalities like hypercholesterolemia and elevated SGOT.
Cardiac changes, including ST depression, T wave abnormalities, and prolonged Q-Tc interval, may occur in multi bacillary leprosy patients.
Further research is warranted to elucidate the clinical significance and underlying mechanisms of these cardiac findings in leprosy.