Related Experiment Video
Updated: Jun 26, 2026

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
Published on: May 25, 2020
A new inotropic aminosteroid: LND 623
Abstract:
It is usually postulated that the side chain attached to 17 beta position on the steroid nucleus of the cardioactive glycosides is a major determinant of their pharmacological activity. A new aminosteroid (LND 623) has been prepared. Despite the fact that the structural features quoted above are lacking, the product demonstrates a strong inotropic effect. LND 623 was active at the same range of concentrations as ouabain or digoxin. However, the maximum increase of the contractile force was significantly higher. The strength of the inotropic action is not modified in the presence of propranolol. The preliminary results suggest that the molecular requirements for the interaction of the drugs with the 'inotropic receptor' may be re-examined.
Related Concept Videos
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Adrenergic Agonists: Direct-Acting Agents
These agents can be classified...
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
Heart Failure Drugs: Inotropic Agents
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

