Testicular changes in the rat by prepuberal administration of a synthetic antiandrogen

The testes of treated animals showed mature spermatozoa and a smaller surface of tubules. Spermatic wave shifted, showing more mitotic figures and less mature spermatozoa. Antiandrogen plus testosterone propionate (TP) and human chorionic gonadotropin (hCG) administration showed, respectively, increased and decreased prostate and testicular weights. Histological aspects of the tubules did not improve by hormonal replacement; instead, altered and multinucleated cells appeared. Testicular modifications showed that antiandrogen administration induced changes in gonadotropin secretion.