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Related Experiment Videos

The mast cell/heparin paradox.

L B Jaques, J Mahadoo, J F Riley

    Lancet (London, England)
    |February 19, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Commercial heparin, a rapid anticoagulant, differs from naturally released mast cell granules. Mast cells release granules containing heparin and other substances, while commercial heparin is stored by different cells, suggesting distinct biological roles.

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    Area of Science:

    • Biochemistry
    • Cell Biology
    • Pharmacology

    Background:

    • Purified heparin from mast cells is a standard rapid anticoagulant.
    • Commercial heparin administration may not mimic natural mast cell degranulation.

    Purpose of the Study:

    • To investigate the discrepancy between commercial heparin and naturally released mast cell granules.
    • To elucidate the cellular uptake and storage mechanisms of heparin.

    Main Methods:

    • Comparative analysis of mast cell granule composition.
    • Investigation of cellular uptake pathways for commercial heparin.
    • Review of historical perspectives on mast cell function.

    Main Results:

    • Mast cell granules contain heparin along with chondroitins, heparitins, histamine, and enzymes.

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  • Commercial heparin is primarily taken up and stored by the reticuloendothelial system.
  • Naturally released granules are ingested and digested by connective-tissue phagocytes.

    • Conclusions:

    • Commercial heparin's pharmacokinetics differ from endogenous heparin release.
    • Mast cells play a broader role in connective tissue beyond simple heparin storage.
    • The mast cell's function is diverse and context-dependent.