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Related Experiment Videos

The insulin concentration in human ocular fluids.

S S Feman, J Turinsky, K W Lam

    American Journal of Ophthalmology
    |March 1, 1978
    PubMed
    Summary
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    In patients with diabetic retinopathy, insulin was detected in subretinal fluid, suggesting a potential leak. However, vitreous fluid in diabetic patients undergoing vitrectomy showed no detectable insulin.

    Area of Science:

    • Ophthalmology
    • Endocrinology
    • Diabetic Retinopathy Research

    Background:

    • Diabetic retinopathy is a leading cause of vision loss.
    • Understanding the role of insulin in ocular fluids is crucial for managing diabetic eye disease.

    Purpose of the Study:

    • To measure insulin concentrations in ocular fluids and serum of patients with and without diabetes mellitus.
    • To investigate the potential presence and origin of insulin in subretinal fluid and vitreous.

    Main Methods:

    • Measurement of immunoreactive insulin in serum, subretinal fluid, and vitreous fluid.
    • Comparison of insulin levels between patients with and without diabetes mellitus, and those with rhegmatogenous retinal detachment or undergoing vitrectomy.

    Main Results:

    Related Experiment Videos

    • Patients with diabetes mellitus and rhegmatogenous retinal detachment had detectable insulin in subretinal fluid, unlike those without diabetes.
    • Serum insulin levels were significantly higher in diabetic patients.
    • Eight out of nine diabetic patients undergoing vitrectomy had undetectable insulin in the vitreous.

    Conclusions:

    • Data suggest a possible small leak of insulin into the subretinal fluid of diabetic patients with retinopathy.
    • Insulin is generally absent in the vitreous of diabetic patients undergoing vitrectomy, despite systemic diabetes.