Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pupil cycle time in optic neuritis.

S D Miller, H S Thompson

    American Journal of Ophthalmology
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Pupil cycle time, a new measurement of optic nerve function, is stable and repeatable. This simple clinical test can detect subclinical optic nerve defects, especially in patients with optic neuritis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tempering allorecognition to induce transplant tolerance with chemically modified apoptotic donor cells.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    First-in-human study of the safety and efficacy of TOL101 induction to prevent kidney transplant rejection.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
    Same author

    Ethnic, racial and cultural identity and perceived benefits and barriers related to genetic testing for breast cancer among at-risk women of African descent in New York City.

    Public health genomics·2011
    Same author

    Iron and CF-related anemia: expanding clinical and biochemical relationships.

    Pediatric pulmonology·2010
    Same author

    Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
    Same author

    99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: triggering of autoimmune diseases by infections.

    Clinical and experimental immunology·2010
    Same journal

    Performance of the ISOLD Score (Interleukin Score for IntraOcular Lymphoma Diagnosis) in the Diagnosis of Vitreoretinal Lymphoma in Clinical Practice.

    American journal of ophthalmology·2026
    Same journal

    Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

    American journal of ophthalmology·2026
    Same journal

    Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

    American journal of ophthalmology·2026
    Same journal

    Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

    American journal of ophthalmology·2026
    See all related articles

    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Clinical Measurement

    Background:

    • The pupil light reflex is a complex neurological process.
    • Assessing optic nerve function typically involves subjective or time-consuming tests.
    • A need exists for objective, quantitative, and rapid clinical tests of optic nerve health.

    Purpose of the Study:

    • To introduce and validate a novel clinical measurement: pupil cycle time (PCT).
    • To assess the repeatability and stability of PCT.
    • To determine the utility of PCT in detecting optic nerve dysfunction, particularly in optic neuritis.

    Main Methods:

    • Utilizing a slit-lamp to illuminate the pupil margin, inducing oscillations.
    • Timing these pupil oscillations with a stopwatch to determine PCT.

    Related Experiment Videos

  • Comparing PCT in healthy individuals and patients with optic neuritis.

    • Main Results:

    • PCT was found to be stable and repeatable within +/- 3% over time.
    • PCT is dependent on iris muscle innervation and optic nerve conduction speed.
    • PCT was significantly longer in patients with optic neuritis (P < .001), indicating subclinical defects.

    Conclusions:

    • Pupil cycle time is a fast, simple, and reliable objective clinical test for assessing optic nerve function.
    • PCT can detect and quantify subclinical optic nerve conduction defects, similar to visual evoked response latency.
    • Inability to measure PCT may indicate a significant abnormality in the light reflex arc.