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Spinal cord injury: diagnostic indicators.

J Rebhun, J G Botvin Madorsky

    Archives of Physical Medicine and Rehabilitation
    |July 1, 1983
    PubMed
    Summary
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    Patients with spinal cord injury often lack a normal skin reaction to histamine below the injury site. Elevated complement levels were also observed, suggesting potential diagnostic value.

    Area of Science:

    • Neuroscience
    • Immunology
    • Dermatology

    Background:

    • Spinal cord injury (SCI) can alter physiological responses.
    • Cutaneous reactions and immune markers in SCI patients require further investigation.

    Purpose of the Study:

    • To investigate the cutaneous reaction to histamine in SCI patients.
    • To assess complement levels in SCI patients.
    • To explore potential diagnostic markers for SCI.

    Main Methods:

    • Intradermal injection of histamine in SCI patients and healthy controls.
    • Comparison of flare skin reactions below the lesion.
    • Measurement of serum complement levels in SCI patients.

    Main Results:

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  • Most SCI patients did not exhibit a flare skin reaction to histamine below the lesion.
  • A majority of SCI patients presented with elevated complement levels.

    • Conclusions:

    • The absence of a flare reaction and elevated complement levels may serve as diagnostic indicators for SCI.
    • Activated complement may contribute to the pathology of spinal cord injury.