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Complement biosynthesis by human bronchoalveolar macrophages.

F S Cole, W J Matthews, T H Rossing

    Clinical Immunology and Immunopathology
    |May 1, 1983
    PubMed
    Summary
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    Bronchoalveolar macrophages from lung disease patients show altered complement production compared to healthy individuals. This suggests pulmonary diseases can impact immune cell function, specifically complement C2, factor B, and C3 secretion.

    Area of Science:

    • Immunology
    • Pulmonary Medicine
    • Cell Biology

    Background:

    • Bronchoalveolar macrophages are key immune cells in the lungs.
    • Complement system proteins play crucial roles in immune responses.
    • Understanding macrophage complement production is vital for lung disease research.

    Purpose of the Study:

    • To investigate complement production by bronchoalveolar macrophages.
    • To compare complement secretion in healthy volunteers versus patients with lung diseases.
    • To determine if pulmonary diseases alter macrophage complement synthesis.

    Main Methods:

    • Collected bronchoalveolar macrophages from 8 healthy volunteers and 15 lung disease patients.
    • Measured complement C2, factor B, and C3 production functionally and immunochemically.

    Related Experiment Videos

  • Cultured macrophages for 48 hours to assess secretion rates.

    • Main Results:

    • Normal macrophages consistently secreted active C2 and factor B.
    • Patient macrophages showed variable or absent C2 and factor B secretion.
    • Normal macrophages secreted C3 protein but not functionally active C3.
    • Three of 15 patients' macrophages produced functional C3.

    Conclusions:

    • Normal bronchoalveolar macrophage complement production differs from blood monocytes.
    • Pulmonary diseases can significantly alter complement production by lung macrophages.
    • These alterations in complement secretion may impact lung disease pathogenesis.