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Diabetes: The quest for basal normoglycaemia.

R R Holman, R C Turner

    Lancet (London, England)
    |February 26, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Basal insulin supplements effectively manage mild diabetes by normalizing blood glucose and triglyceride levels. This treatment, using Ultralente insulin, offers a low-risk alternative when diet alone is insufficient for diabetes control.

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    Area of Science:

    • Endocrinology
    • Metabolic Diseases

    Background:

    • Diabetes mellitus is characterized by endocrine deficiency, often leading to elevated plasma-glucose levels despite dietary management.
    • Elevated basal plasma glucose concentration is a primary abnormality in diabetes requiring targeted treatment for basal normoglycaemia.

    Purpose of the Study:

    • To evaluate the efficacy of basal insulin supplementation in mild, maturity-onset diabetes.
    • To assess the impact of basal insulin therapy on plasma-glucose and plasma-triglyceride levels.

    Main Methods:

    • Treatment of 18 mild diabetics with daily injections of insulin zinc suspension (Ultralente).
    • Monitoring of overnight basal normoglycaemia and daytime plasma-glucose levels.
    • Assessment of plasma-triglyceride levels and calculation of insulin dosage based on basal glucose and obesity.

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    Main Results:

    • Achieved overnight basal normoglycaemia in all patients.
    • Markedly reduced daytime plasma-glucose levels.
    • Normalized plasma-triglyceride levels in most patients.
    • Demonstrated minimal risk of hypoglycaemia and reduced need for dietary restrictions.

    Conclusions:

    • Basal insulin supplementation with Ultralente is effective for managing mild diabetes when diet fails.
    • Insulin dosage can be calculated, minimizing empirical determination and risk.
    • This therapeutic approach may prevent complications in mild diabetics by achieving basal normoglycaemia.