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[Therapeutic effects of an ampicillin suppository KS-R1) on infections in children]
Insights
Ampicillin suppositories (KS-R1) effectively treated pediatric infections, showing good clinical outcomes and pathogen eradication. Some patients experienced mild side effects like diarrhea or elevated GOT.
Area of Science:
- Pediatric infectious diseases
- Pharmacology
- Antimicrobial therapy
Context:
- Urinary tract infections (UTIs) and upper respiratory tract infections (URTIs) are common in children.
- Antibiotic resistance necessitates evaluating alternative drug formulations and delivery methods.
Purpose:
- To evaluate the clinical and bacteriological efficacy of ampicillin suppositories (KS-R1) in pediatric patients.
- To assess the safety profile of ampicillin suppositories in children.
Summary:
- Ampicillin suppositories demonstrated significant clinical effectiveness, with 19 out of 22 children showing excellent or good responses.
- Bacteriological eradication or reduction of pathogens was observed in 7 out of 11 treated cases.
- Reported side effects included watery diarrhea and elevated GOT, indicating a generally manageable safety profile.
Impact:
- Findings suggest ampicillin suppositories (KS-R1) are a viable and useful therapeutic option for pediatric infections.
- This formulation may offer an alternative for children who have difficulty with oral or intravenous administration.
- Further research could explore optimal dosing and long-term outcomes for this drug delivery method.
Abstract:
Clinical and bacteriological effects of ampicillin suppository (KS-R1) were determined in 9 cases with urinary tract infection and 13 cases with upper respiratory tract infection in children. Clinical effects were excellent in 1 case, good in 18 cases, fair in 2 cases and poor in 1 case. Bacteriological effects were eradication in 6 cases, decrease in 1 case, persistance in 3 cases and replacement in 1 case among 11 cases which were measured the pathogens before and after treatment. As to the side effects, one patient showed watery diarrhea, and another one showed the elevation of GOT. KS-R1 is considered to be a useful drug for the treatment of infection in children both clinically and bacteriologically.