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HLA-linked complement polymorphisms (C2, BF) in psoriasis.

G Dewald, C E Lange, E Schmeel

    Archives of Dermatological Research
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    This study investigated the association between psoriasis and complement system allotypes. Researchers found specific rare complement genes (C2*2, BF*SO7) were more frequent in psoriasis patients, while BF*F was less frequent, suggesting a link.

    Area of Science:

    • Immunogenetics
    • Dermatology
    • Complement System Biology

    Background:

    • Psoriasis is known to be associated with specific Human Leukocyte Antigen (HLA) antigens.
    • The HLA chromosomal region encodes for complement components, including C2 and BF.
    • Previous research suggests a potential link between complement system variations and psoriasis susceptibility.

    Purpose of the Study:

    • To investigate the association between psoriasis and genetic variations (allotypes) of complement components C2 and BF.
    • To determine if specific alleles of C2 and BF are more prevalent in individuals with psoriasis.
    • To explore the relationship between these complement allotypes and known HLA associations in psoriasis.

    Main Methods:

    • Analysis of C2 and BF polymorphism in a cohort of 230 psoriatic patients.

    Related Experiment Videos

  • Comparison of allele frequencies of C2 and BF between psoriatic patients and a control group.
  • Calculation of relative risks for specific C2 and BF alleles in relation to psoriasis.

    • Main Results:

    • Significantly increased frequencies of rare complement genes C2*2 (0.061 vs 0.035) and BF*SO7 (0.0304 vs 0.0092) were observed in psoriatic patients compared to controls.
    • A significantly decreased frequency of the BF*F gene (0.1196 vs 0.1743) was found in psoriatic patients.
    • Relative risks indicated an increased susceptibility associated with C2*2 (1.79) and BF*SO7 (3.44), and decreased susceptibility with BF*F (0.6).

    Conclusions:

    • The study identifies significant associations between specific C2 and BF allotypes and psoriasis.
    • These findings support a role for the complement system in the pathogenesis of psoriasis.
    • The identified complement alleles are in linkage disequilibrium with HLA alleles previously associated with psoriasis, reinforcing the genetic connection.