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Activity of eleven antimicrobial agents against methicillin-, methicillin- and rifampin-resistant Staphylococcus
Abstract:
Activity of eleven antimicrobial agents against methicillin-, methicillin- and rifampin-resistant Staphylococcus aureus was studied using a microtiter broth dilution technique. Coumermycin was the most active agent. Vancomycin, rifampin, fusidic acid and N-formimidoyl-thienamycin showed excellent activity against methicillin-resistant St. aureus (MRSA). Antimicrobial susceptibility pattern was similar for MRSA and methicillin- and rifampin-resistant St. aureus. 8% of MRSA were resistant to trimethoprim and sulfamethoxazole.
Insights
Coumermycin showed the highest activity against resistant Staphylococcus aureus strains. Other agents like vancomycin were also effective against methicillin-resistant St. aureus (MRSA).
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat due to its resistance to common antibiotics.
- Emergence of strains resistant to multiple drugs, including rifampin, necessitates the evaluation of alternative antimicrobial agents.
Purpose of the Study:
- To assess the in vitro activity of eleven antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA) and strains resistant to both methicillin and rifampin.
- To compare the efficacy of different antibiotics in combating resistant Staphylococcus aureus strains.
Main Methods:
- A microtiter broth dilution technique was employed to determine the minimum inhibitory concentrations (MICs) of eleven antimicrobial agents.
- Susceptibility testing was performed on isolates of methicillin-resistant Staphylococcus aureus (MRSA) and strains resistant to both methicillin and rifampin.
Main Results:
- Coumermycin demonstrated the most potent activity against all tested resistant Staphylococcus aureus strains.
- Vancomycin, rifampin, fusidic acid, and N-formimidoyl-thienamycin exhibited excellent activity against MRSA.
- The antimicrobial susceptibility patterns were comparable between MRSA and strains resistant to both methicillin and rifampin.
- A small proportion (8%) of MRSA isolates showed resistance to trimethoprim and sulfamethoxazole.
Conclusions:
- Coumermycin is a promising agent for treating infections caused by resistant Staphylococcus aureus.
- Several established antibiotics retain significant activity against MRSA, but the emergence of multi-drug resistance warrants continued surveillance and development of new therapies.