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Related Experiment Videos

A second look at emepronium bromide in urinary incontinence.

A E Ritch, C F George, C M Castleden

    Lancet (London, England)
    |March 5, 1977
    PubMed
    Summary

    Intramuscular emepronium bromide effectively treated urinary incontinence by increasing bladder capacity. Oral emepronium bromide showed limited efficacy due to poor absorption, impacting bladder function and propranolol response.

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    Area of Science:

    • Pharmacology
    • Urology

    Background:

    • Uninhibited bladder dysfunction causes urinary incontinence.
    • Emepronium bromide is investigated for its potential therapeutic effects.

    Purpose of the Study:

    • To assess the efficacy of oral and intramuscular emepronium bromide in treating urinary incontinence.
    • To evaluate the impact of oral emepronium bromide on bladder capacity and spasm.
    • To investigate the interaction between oral emepronium bromide and propranolol absorption.

    Main Methods:

    • Cystometric evaluation in nine patients with uninhibited bladder incontinence.
    • Administration of oral and intramuscular emepronium bromide.
    • Measurement of plasma-propranolol response and concentrations after co-administration.

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    Main Results:

    • Intramuscular emepronium bromide increased bladder capacity and delayed bladder spasm and desire to void.
    • Oral emepronium bromide did not affect bladder capacity or function.
    • Oral emepronium bromide delayed plasma-propranolol response and reduced its concentrations.

    Conclusions:

    • Intramuscular emepronium bromide is effective for treating urinary incontinence.
    • Oral emepronium bromide absorption is insufficient to impact bladder function.
    • Oral emepronium bromide may influence the pharmacokinetics of other medications like propranolol.