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Effect of morphine on splanchnic blood flow.
British Heart Journal
|May 1, 1978
Summary
Morphine administration significantly increased splanchnic blood flow and decreased splanchnic vascular resistance in patients. This indicates that morphine causes dilation of the splanchnic arterioles.
Area of Science:
- Pharmacology
- Physiology
- Hepatology
Background:
- Splanchnic blood flow is crucial for liver function and drug metabolism.
- Understanding the effects of opioids on splanchnic circulation is important for clinical practice.
Purpose of the Study:
- To investigate the impact of intravenous morphine on splanchnic blood flow and resistance.
- To determine if morphine causes significant changes in splanchnic hemodynamics.
Main Methods:
- Utilized constant infusion of indocyanine green to measure splanchnic blood flow.
- Administered morphine intravenously at a dose of 0.2 mg/kg (maximum 15 mg) to 13 patients.
- Monitored systemic arterial pressure, hepatic vein wedge pressure, and right atrial mean pressure.
Main Results:
- Splanchnic blood flow increased by 19% (1012 to 1200 ml/min, P<0.025) post-morphine.
- Splanchnic vascular resistance decreased by 16% (0.094 to 0.081 mmHg min/ml, P<0.001).
- No significant changes observed in systemic arterial pressure, hepatic vein wedge pressure, or right atrial pressure.
Conclusions:
- Morphine induces significant splanchnic arteriolar dilatation.
- Opioid administration can alter splanchnic hemodynamics.
- These findings have implications for drug administration and patient monitoring.
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