Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemodialysis leukopenia and complement function with different dialyzers.

A Amadori, P Candi, M Sasdelli

    Kidney International
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Navigate Transcranial Magnetic Stimulation Is More Reliable Than Tractography for Placing Subdural Electrodes Used for Cortico-Cortical-Evoked-Potentials Recording.

    World neurosurgery·2025
    Same author

    Containment of carbapenem-resistant Enterobacterales colonisations and infections: Results from an integrated infection control intervention in a large hospital trust of northern Italy.

    American journal of infection control·2023
    Same author

    Musladin-Lueke Syndrome in a Dog: Case Report.

    Topics in companion animal medicine·2022
    Same author

    An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts.

    Cell death & disease·2016
    Same author

    Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation.

    Leukemia·2015
    Same author

    Predictive markers in elderly patients with estrogen receptor-positive breast cancer treated with aromatase inhibitors: an array-based pharmacogenetic study.

    The pharmacogenomics journal·2015
    Same journal

    KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

    Kidney international·2026
    Same journal

    KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

    Kidney international·2026
    Same journal

    Crystal-Storing Histiocytosis Causing Severe AKI.

    Kidney international·2026
    Same journal

    Peritoneal dialysis in a patient with extensive burn scarring.

    Kidney international·2026
    Same journal

    COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

    Kidney international·2026
    Same journal

    Monitoring anti-nephrin antibodies in the management of recurrent diffuse podocytopathy.

    Kidney international·2026
    See all related articles

    Hemodialysis leukopenia is linked to complement system activation, specifically chemotactic factor generation by dialyzer membranes. In vitro studies revealed membrane material significantly impacts this complement response and leukocyte count changes.

    Area of Science:

    • Nephrology
    • Immunology
    • Biomaterials Science

    Background:

    • Hemodialysis can cause leukopenia (low white blood cell count).
    • The complement system, part of innate immunity, is implicated in this process.
    • Dialyzer membrane material is suspected to influence complement activation.

    Purpose of the Study:

    • To re-examine the relationship between hemodialysis-induced leukopenia and the complement system.
    • To investigate the in vitro and in vivo effects of different dialyzer membranes on leukocyte counts and complement function.
    • To elucidate the mechanisms behind hemodialysis leukopenia.

    Main Methods:

    • Studied four dialyzer membranes: cellulose hydrate, cuprophan, cellulose acetate, and polyacrylonitrile.
    • Assessed in vivo effects on leukocyte counts and complement levels.

    Related Experiment Videos

  • Investigated in vitro effects on complement function and chemotactic factor generation.

    • Main Results:

    • In vivo studies yielded inconclusive results regarding leukopenia.
    • In vitro investigations demonstrated a strong correlation between dialyzer membrane-induced leukopenia and chemotactic factor generation.
    • Polyacrylonitrile's effect on complement function was due to adsorption, not consumption, explaining the lack of granulocyte decrease.

    Conclusions:

    • Hemodialysis leukopenia is primarily driven by complement system activation and subsequent chemotactic factor generation.
    • Dialyzer membrane properties critically influence the complement response and leukopenia.
    • Understanding these interactions is key to preventing hemodialysis-induced complications.