Familial lichen planus. A case report

Area of Science:

• Dermatology
• Genetics
• Medical Science

Background:

• Lichen planus is an inflammatory condition affecting skin and mucous membranes.
• Familial aggregation of lichen planus suggests a potential genetic component.
• Human Leukocyte Antigen (HLA) phenotypes are often investigated for associations with autoimmune and inflammatory diseases.

Observation:

• A specific Jewish Shirazee family presented with six affected members diagnosed with lichen planus.
• Clinical presentation and family history were documented for all affected individuals.

Findings:

• The affected family members exhibited lichen planus, indicating a possible familial predisposition.
• No statistically significant increase in the Human Leukocyte Antigen A3 (HLA A3) phenotype was observed among the affected family members.
• This suggests that HLA A3 may not be a primary genetic factor in this specific family's lichen planus cases.

Implications:

• The findings contribute to understanding the genetic underpinnings of lichen planus.
• Further research into other genetic markers may be warranted to elucidate the etiology of familial lichen planus.
• This case highlights the importance of considering family history in the diagnosis and management of lichen planus.