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Familial lichen planus. A case report.

M Sodaify, D I Vollum

    The British Journal of Dermatology
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    A Jewish Shirazee family showed a high incidence of lichen planus among six members. However, the study found no increased occurrence of the HLA A3 phenotype in affected individuals.

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    Area of Science:

    • Dermatology
    • Genetics
    • Medical Science

    Background:

    • Lichen planus is an inflammatory condition affecting skin and mucous membranes.
    • Familial aggregation of lichen planus suggests a potential genetic component.
    • Human Leukocyte Antigen (HLA) phenotypes are often investigated for associations with autoimmune and inflammatory diseases.

    Observation:

    • A specific Jewish Shirazee family presented with six affected members diagnosed with lichen planus.
    • Clinical presentation and family history were documented for all affected individuals.

    Findings:

    • The affected family members exhibited lichen planus, indicating a possible familial predisposition.
    • No statistically significant increase in the Human Leukocyte Antigen A3 (HLA A3) phenotype was observed among the affected family members.

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  • This suggests that HLA A3 may not be a primary genetic factor in this specific family's lichen planus cases.

    • Implications:

    • The findings contribute to understanding the genetic underpinnings of lichen planus.
    • Further research into other genetic markers may be warranted to elucidate the etiology of familial lichen planus.
    • This case highlights the importance of considering family history in the diagnosis and management of lichen planus.