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Cross-resistance between methicillin and cephalosporins for staphylococci: a general assumption not true for
Abstract:
The antibacterial activity of cefamandole was evaluated against 120 methicillin-susceptible and methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococcal strains, using both large (10(8) CFU per ml) and small (10(4) CFU per ml) inocula. Cefamandole appeared superior to cephalothin against methicillin-resistant strains, displaying at 10 micrograms/ml a bacteriostatic and for some strains a bactericidal action against a large inoculum of bacteria.
Insights
Cefamandole shows antibacterial effectiveness against Staphylococcus aureus, including resistant strains. It demonstrated bacteriostatic and sometimes bactericidal action, outperforming cephalothin against methicillin-resistant bacteria.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Staphylococcus aureus, including methicillin-resistant strains (MRSA), poses a significant public health threat.
- The emergence of antibiotic resistance necessitates the evaluation of existing and novel antibacterial agents.
- Cephalothin has known limitations against certain resistant bacterial populations.
Purpose of the Study:
- To evaluate the antibacterial activity of cefamandole.
- To compare cefamandole's efficacy against cephalothin, particularly in methicillin-resistant Staphylococcus aureus (MRSA) strains.
- To assess the impact of inoculum size on cefamandole's activity.
Main Methods:
- Antibacterial activity testing of cefamandole.
- In vitro evaluation against 120 strains of Staphylococcus aureus (methicillin-susceptible and methicillin-resistant) and coagulase-negative staphylococci.
- Use of both large (10(8) CFU/ml) and small (10(4) CFU/ml) inocula.
Main Results:
- Cefamandole demonstrated antibacterial activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains.
- At 10 µg/ml, cefamandole exhibited bacteriostatic and, in some cases, bactericidal effects against large inocula.
- Cefamandole showed superior activity compared to cephalothin against methicillin-resistant strains.
Conclusions:
- Cefamandole is a viable option for treating infections caused by Staphylococcus aureus, including MRSA.
- The drug's effectiveness is notable even at high bacterial concentrations.
- Cefamandole presents an advantage over cephalothin in combating resistant Staphylococcus aureus infections.