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Human plasma prekallikrein and high molecular weight kininogen decrease during parturition.

B M Alving, J R Niebyl, D Proud

    Thrombosis Research
    |June 15, 1984
    PubMed
    Summary
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    During childbirth, key proteins in the kallikrein-kinin system, prekallikrein and high molecular weight kininogen, significantly decrease. These levels return to normal shortly after birth, indicating system utilization during parturition.

    Area of Science:

    • Biochemistry
    • Physiology
    • Obstetrics

    Background:

    • The kallikrein-kinin system plays a role in various physiological processes.
    • Understanding its function during parturition is crucial for obstetric research.

    Purpose of the Study:

    • To quantify prekallikrein and high molecular weight kininogen levels in women during labor and postpartum.
    • To investigate the involvement of the kallikrein-kinin system in the physiological events of parturition.

    Main Methods:

    • Plasma samples were collected from nine women during early labor and at one and two days postpartum.
    • Prekallikrein and high molecular weight kininogen concentrations were measured using established biochemical assays.

    Main Results:

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  • A significant decrease in prekallikrein levels was observed from early labor to the immediate postpartum period (p < 0.01).
  • High molecular weight kininogen also showed a significant reduction one day postpartum compared to early labor levels (p < 0.01).
  • Both protein levels normalized within two days postpartum.

    • Conclusions:

    • The study indicates significant utilization of the kallikrein-kinin system during parturition.
    • The observed decrease and subsequent normalization of prekallikrein and high molecular weight kininogen suggest a dynamic role in childbirth.