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Related Experiment Videos

Total deafness from aminoglycoside overdosage: histopathologic case study.

L G Johnsson, J E Hawkins, J M Weiss

    American Journal of Otolaryngology
    |March 1, 1984
    PubMed
    Summary

    Excessive doses of the antibiotic lividomycin caused total deafness in a patient due to severe cochlear hair cell loss. Vestibular organs also showed damage, indicating widespread ototoxicity from the drug.

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    Area of Science:

    • Ototoxicology
    • Neuroscience
    • Pathology

    Background:

    • Aminoglycosidic antibiotics, like lividomycin, are known for potential ototoxicity.
    • This case examines the pathological effects of excessive parenteral lividomycin administration.

    Observation:

    • A patient developed profound deafness two days after a 14-day course of excessive lividomycin.
    • Temporal bone examination revealed near-complete loss of cochlear hair cells and vestibular hair cells.
    • Pathological findings included refractile concretions in the stria vascularis and degeneration of cochlear nerve fibers.

    Findings:

    • Severe ototoxicity, including cochlear and vestibular hair cell destruction, was confirmed.
    • Damage to the spiral ganglion and alterations in vestibular dark cells were observed.

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  • The findings correlate excessive lividomycin dosage with significant auditory and vestibular impairment.

    • Implications:

    • This case highlights the critical importance of appropriate antibiotic dosing to prevent irreversible ototoxicity.
    • Understanding the pathological mechanisms of antibiotic-induced hearing loss is crucial for patient safety.
    • Further research into lividomycin's ototoxic potential and safe dosage ranges is warranted.