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Related Experiment Videos

Brainstem auditory evoked responses and quantitative saccade studies in multiple sclerosis: a comparative evaluation.

W Knezevic, F L Mastaglia, J L Black

    Clinical and Experimental Neurology
    |January 1, 1984
    PubMed
    Summary

    Brainstem auditory evoked responses (BAERs) and saccade eye movement studies detect brainstem pathway damage in multiple sclerosis. Saccade studies revealed more abnormalities than BAERs, suggesting a complementary diagnostic role.

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    Area of Science:

    • Neuroscience
    • Neurology

    Background:

    • Brainstem auditory evoked responses (BAERs) and quantitative saccadic eye movement studies assess brainstem pathway integrity.
    • Multiple sclerosis (MS) can affect these pathways, necessitating sensitive diagnostic tools.

    Purpose of the Study:

    • To compare the diagnostic yield of BAERs and saccade studies in patients with multiple sclerosis.
    • To determine the complementary role of these neurophysiological tests in MS investigation.

    Main Methods:

    • Analysis of findings from 46 patients with clinically defined, probable, or suspected multiple sclerosis.
    • Both BAERs and quantitative saccade eye movement studies were performed on all participants.

    Main Results:

    • BAERs were abnormal in 39% of cases (22% subclinical).

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  • Saccade studies showed abnormalities in 67% (41% subclinical), affecting reaction time, velocity, or accuracy.
  • Combined, the tests revealed abnormalities in 76% of patients, with 52% being subclinical.

    • Conclusions:

    • Quantitative saccade studies appear more sensitive than BAERs for detecting brainstem abnormalities in MS.
    • Both BAERs and saccade studies offer complementary information, enhancing the overall diagnostic capability for multiple sclerosis.