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Hemidesmosome-like intercellular specializations in human meningiomas.

D D Copeland, S W Bell, J D Shelburne

    Cancer
    |June 1, 1978
    PubMed
    Summary

    Researchers identified a novel intercellular junction in human meningiomas, distinct from known types. This finding supports meningiomas originating from arachnoidal cells and may aid in diagnosing metastatic meningiomas.

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    Area of Science:

    • Neuroscience
    • Oncology
    • Cell Biology

    Background:

    • Human meningiomas exhibit desmosomes, gap junctions, and tight junctions.
    • A fourth type of intercellular specialization has been observed in meningiomas.

    Purpose of the Study:

    • To characterize a novel intercellular specialization in human meningiomas.
    • To investigate the potential origin of meningiomas from arachnoidal cells.
    • To evaluate the utility of this junction as a diagnostic marker for metastatic meningiomas.

    Main Methods:

    • Microscopic examination of five human meningioma samples, including a pulmonary metastasis.
    • Comparative analysis of intercellular specializations in meningiomas, arachnoidal cells, and dural fibroblasts.

    Main Results:

    • A fourth type of intercellular specialization, similar but not identical to epidermal hemidesmosomes, was consistently found in all meningioma samples.
    • Identical intercellular specializations were observed between arachnoidal cells but not dural fibroblasts.
    • These junctions were present in both benign intracranial tumors and a pulmonary metastasis.

    Conclusions:

    • The presence of this novel junction supports the arachnoidal epithelial origin of meningiomas.
    • This intercellular specialization may serve as a valuable morphologic marker for diagnosing extracranial metastatic meningiomas.

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