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Related Experiment Videos

Depth pulse sequences for surface coils: spatial localization and T1 measurements.

T C Ng, J D Glickson, M R Bendall

    Magnetic Resonance in Medicine
    |December 1, 1984
    PubMed
    Summary
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    New pulse sequences using a surface coil enable precise localization for in vivo phosphorus-31 (31P) magnetic resonance imaging. This technique allows for detailed monitoring of biological tissues and tumor detection.

    Area of Science:

    • Biomedical Engineering
    • Magnetic Resonance Imaging
    • Nuclear Magnetic Resonance Spectroscopy

    Background:

    • Phosphorus-31 (31P) magnetic resonance imaging (MRI) offers unique insights into cellular metabolism and tissue viability.
    • Accurate spatial localization is crucial for targeted 31P MRI studies.
    • Developing advanced pulse sequences is key to improving resolution and sensitivity.

    Purpose of the Study:

    • To implement and validate novel depth pulse sequences for enhanced spatial localization in 31P MRI.
    • To assess the capability of these sequences for in vivo tissue monitoring and tumor detection.
    • To utilize an inversion-recovery sequence for measuring spin-lattice relaxation times in selected regions.

    Main Methods:

    • Implementation of depth pulse sequences (theta;[2 theta(+/- x, +/- y)]2 and 2 theta;theta(+/- x);[2 theta(+/- x, +/- y)]2) with a two-turn surface coil at 31P resonance (89.96 MHz).

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  • Localization was verified using phantom samples, in vivo rat livers, and subcutaneously implanted tumors.
  • An inversion-recovery pulse sequence (2 theta-tau-theta(+/- x);[2 theta(+/- x, +/- y)]2) was used to measure spin-lattice relaxation times (T1).

    • Main Results:

    • Successful localization of the sensitive region was demonstrated using the implemented pulse sequences.
    • In vivo monitoring of rat livers and detection of necrotic regions in tumors were achieved.
    • The spin-lattice relaxation time (T1) of selected regions could be measured and varied by adjusting pulse width and coil size.

    Conclusions:

    • The developed depth pulse sequences provide effective spatial localization for 31P MRI.
    • This technique is valuable for in vivo metabolic studies, enabling precise tissue analysis and tumor characterization.
    • The ability to measure T1 relaxation times adds quantitative metabolic information to localized 31P MRI data.