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Intravenous disopyramide in myocardial infarction: a haemodynamic study
The New Zealand Medical Journal
|January 12, 1983
Summary
Disopyramide administration in myocardial infarction patients increased heart rate and pulmonary pressures, but decreased stroke volume, indicating a negative inotropic effect. These hemodynamic changes were observed shortly after intravenous disopyramide injection.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Myocardial infarction (MI) is a critical condition affecting heart function.
- Understanding the hemodynamic effects of antiarrhythmic drugs is crucial for patient management.
Purpose of the Study:
- To evaluate the hemodynamic effects of disopyramide in patients with recent myocardial infarction.
- To assess the inotropic and vascular effects of disopyramide.
Main Methods:
- Intravenous administration of disopyramide (2 mg/kg over 10 minutes) to 14 patients within 36 hours of MI.
- Monitoring of hemodynamic parameters including heart rate, wedge pressure, stroke volume, systemic vascular resistance, and pulmonary arterial pressure.
Main Results:
- Disopyramide caused a significant increase in heart rate and pulmonary arterial pressures.
- A decrease in stroke volume and an increase in systemic vascular resistance were observed.
- Disopyramide demonstrated a negative inotropic effect on the heart, with peak plasma levels at five minutes post-injection.
Conclusions:
- Disopyramide exerts significant hemodynamic effects in patients with acute myocardial infarction.
- The observed negative inotropic effect and alterations in vascular resistance warrant careful consideration in clinical application.