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Normal platelet function after therapy for acute lymphocytic leukemia.

C H Pui, C W Jackson, C Chesney

    Archives of Internal Medicine
    |January 1, 1983
    PubMed
    Summary
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    Platelet aggregation responses in acute lymphocytic leukemia (ALL) survivors are generally normal. This study found no significant platelet defects in long-term survivors, suggesting chemotherapy or leukemia does not cause frequent issues.

    Area of Science:

    • Hematology
    • Oncology
    • Platelet Biology

    Background:

    • Acute lymphocytic leukemia (ALL) is a common childhood cancer.
    • Chemotherapy for ALL can have long-term side effects.
    • Platelet dysfunction is a potential concern in cancer survivors.

    Purpose of the Study:

    • To investigate platelet aggregation responses in long-term survivors of acute lymphocytic leukemia (ALL).
    • To determine if ALL or its treatment causes persistent platelet defects.

    Main Methods:

    • Studied platelet aggregation in vitro and in vivo.
    • Tested responses to adenosine diphosphate (ADP), epinephrine, and collagen.
    • Analyzed 19 patients in remission for 2 months to 4.8 years.

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    Main Results:

    • Most patients showed normal platelet aggregation responses to various stimuli.
    • One patient exhibited abnormal aggregation to a low concentration of ADP.
    • The mean platelet-aggregate ratio was within the normal range.

    Conclusions:

    • Platelet defects are not a common occurrence in long-term survivors of ALL.
    • Late effects of ALL or chemotherapy on platelet function appear infrequent.