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Epithelial tissue-derived growth factor-like polypeptides.

J Halper, H L Moses

    Cancer Research
    |May 1, 1983
    PubMed
    Summary
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    Malignant SW-13 cells show increased growth in soft agar when stimulated by epithelial growth factors. These factors are heat-stable polypeptides, distinct from previously identified growth factors.

    Area of Science:

    • Cell Biology
    • Biochemistry
    • Oncology

    Background:

    • SW-13 cells, derived from human adrenal cortex adenocarcinoma, exhibit limited anchorage-independent growth.
    • Autostimulation by serum-free conditioned medium suggests potential growth factors within SW-13 cells.

    Purpose of the Study:

    • To investigate the factors stimulating soft agar colony formation in SW-13 cells.
    • To characterize the nature and origin of these growth-promoting substances.

    Main Methods:

    • Assessing SW-13 cell colony formation in soft agar after stimulation with conditioned media and cell extracts.
    • Testing extracts from various human carcinoma and non-neoplastic tissues.
    • Chemical and physical characterization of the active substances, including molecular weight determination and chromatography.

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    Main Results:

    • Epithelial tissue-derived growth factor-like polypeptides significantly increased SW-13 cell colony number and size.
    • Extracts from human carcinomas and some non-neoplastic tissues stimulated SW-13 growth, while non-epithelial tumors did not.
    • The active substances are acid- and heat-stable polypeptides (20-22 kDa) separable from other known growth factors.

    Conclusions:

    • SW-13 cells are stimulated by specific epithelial growth factors, suggesting autocrine or paracrine signaling in adrenal cortex adenocarcinoma.
    • These growth factors are distinct polypeptides with unique biochemical properties.
    • The findings contribute to understanding tumor cell growth regulation and identifying potential therapeutic targets.