Follicular lymphoid hyperplasia of the hard palate: a benign lymphoproliferative process

Follicular lymphoid hyperplasia of the hard palate is a reactive lymphoid proliferation which closely simulates the palatal lymphomas, both clinically and histologically. It is therefore imperative that the pathologist be familiar with the features that separate these two conditions. In equivocal cases like the present one, immunologic analysis would seem to be indicated to determine whether the lesion is monoclonal (neoplastic) or polyclonal (reactive).