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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

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Published on: June 13, 2014

Enhancement of immune function and tumor growth inhibition by antibodies against prostaglandin E2

M R Young, M Dizer

    Immunological Communications
    |January 1, 1983
    PubMed

    Mice bearing a Lewis lung carcinoma (LLC) were passively immunized against prostaglandin E2 (PGE2) by administration of rabbit serum containing anti-PGE2 antibodies. The effect of PGE2-immune serum on the suppressed immunity of LLC-bearing mice was examined. Treatment of tumor-bearing mice with anti-PGE2 prevented the suppression of lymphocyte mitogenesis and the alterations in macrophage migration which typically occur in LLC-bearing mice. Furthermore, tumor growth was reduced in LLC-bearing mice which received antibodies directed against PGE2 rather than a placebo treatment.

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