Susceptibility of bacterial pathogens to cefotetan judged by MIC and disc tests

The activity of cefotetan was tested against 683 bacterial strains by measuring the minimum inhibitory concentrations. Comparisons were made with cefoxitin, cefotaxime, moxalactam, cefoperazone and piperacillin. In addition, a regression line analysis was made with cefotetan discs (30 micrograms) using the ICS technique. Cefotetan was noted to have a broader spectrum of activity than cefoxitin and its antibacterial activity was comparable to that of cefotaxime and moxalactam. According to the regression line analysis a cefotetan inhibition zone diameter of greater than or equal 19 mm is interpreted as sensitive in agar diffusion tests.