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Raised plasma thromboxane B2 levels in alcoholic liver disease
Prostaglandins, Leukotrienes, and Medicine
|February 1, 1983
Summary
Elevated thromboxane B2 levels were observed in patients with alcoholic liver cirrhosis, correlating with poorer health indicators. These findings suggest thromboxanes may contribute to complications in liver cirrhosis.
Area of Science:
- Biochemistry
- Hepatology
- Internal Medicine
Background:
- Endotoxemia is a common complication in liver cirrhosis.
- Endotoxin administration in animals increases thromboxane B2 and prostaglandin levels.
- Thromboxanes play a role in various physiological and pathological processes.
Purpose of the Study:
- To investigate plasma thromboxane B2 levels in patients with alcoholic liver cirrhosis.
- To explore the association between thromboxane B2 levels and clinical parameters in these patients.
Main Methods:
- Measurement of plasma thromboxane B2 levels in sixteen patients with alcoholic liver cirrhosis.
- Correlation analysis of thromboxane B2 levels with serum urea, alkaline phosphatase, gamma glutamyl transpeptidase, antiplasmin, and antithrombin III.
Main Results:
- Twelve out of sixteen patients exhibited elevated plasma thromboxane B2 levels on at least one occasion.
- Raised thromboxane B2 levels were significantly associated with higher serum urea, alkaline phosphatase, and gamma glutamyl transpeptidase.
- Elevated thromboxane B2 levels correlated with lower antiplasmin and antithrombin III levels.
Conclusions:
- Patients with alcoholic liver cirrhosis frequently present with elevated plasma thromboxane B2.
- Thromboxane B2 elevation is linked to markers of liver dysfunction and impaired coagulation/anticoagulation.
- Thromboxanes may mediate certain complications observed in alcoholic liver cirrhosis.