Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clonal evolution in a human neuroblastoma.

M K Feder, F Gilbert

    Journal of the National Cancer Institute
    |June 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    This study tracked neuroblastoma clonal evolution by analyzing tumor samples over time. Different selection pressures led to distinct chromosomal abnormalities in metastases and derived tumors, highlighting tumor heterogeneity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Beyond Threat: Changes in Visuocortical Engagement and Oscillatory Brain Activity during Non-Aversive Associative Learning.

    bioRxiv : the preprint server for biology·2025
    Same author

    Door-to-puncture time in ischemic stroke with large vessel occlusion in France: Patient and hospital factors.

    Revue neurologique·2025
    Same author

    International Regulatory Standards for the Qualitative Measurement of Deep Brain Stimulation in Clinical Research.

    Journal of empirical research on human research ethics : JERHRE·2022
    Same author

    Reduced hypertrophy in vitro after chondrogenic differentiation of adult human mesenchymal stem cells following adenoviral SOX9 gene delivery.

    BMC musculoskeletal disorders·2020
    Same author

    The inflamed biceps tendon as a pain generator in the shoulder: A histological and biomolecular analysis.

    Journal of orthopaedic surgery (Hong Kong)·2019
    Same author

    Clinical implications of fracture-associated vascular damage in extremity and pelvic trauma.

    BMC musculoskeletal disorders·2018
    Same journal

    Cluster randomized controlled trial of decision support for breast cancer chemoprevention, MiCHOICE.

    Journal of the National Cancer Institute·2026
    Same journal

    Beyond R2: Assessing quality of trial level surrogate endpoints in colorectal cancer.

    Journal of the National Cancer Institute·2026
    Same journal

    A novel classification of small bowel adenocarcinoma based on the hidden genome classifier: a multi-institutional study.

    Journal of the National Cancer Institute·2026
    Same journal

    Response to Yu, Wang and Ge.

    Journal of the National Cancer Institute·2026
    Same journal

    Re: Cardiovascular disease risk after radiotherapy and anthracycline-based chemotherapy for diffuse large B-cell lymphoma.

    Journal of the National Cancer Institute·2026
    Same journal

    Welcome reduction of US cervical cancer rates despite state differences.

    Journal of the National Cancer Institute·2026
    See all related articles

    Area of Science:

    • Oncology
    • Genetics
    • Cancer Research

    Background:

    • Neuroblastoma is a pediatric cancer characterized by significant cellular and genetic heterogeneity.
    • Understanding tumor evolution is crucial for developing effective treatment strategies.

    Observation:

    • Tumor samples from a single neuroblastoma patient were analyzed at different stages of illness and after xenotransplantation.
    • Primary tumor cells showed chromosomal number heterogeneity, while metastases and xenograft tumors exhibited distinct modal chromosome numbers (diploid and hypotriploid, respectively).

    Findings:

    • All analyzed tumor samples shared common marker chromosome rearrangements, confirming a shared clonal origin.
    • Each sample and cell line displayed unique chromosomal abnormalities, indicating divergent evolution under varying selection pressures.

    Related Experiment Videos

  • Karyotypic differences between primary tumors, metastases, and xenografts reflect adaptation to different microenvironments.

    • Implications:

    • This study provides insights into the dynamic nature of tumor evolution and clonal selection in neuroblastoma.
    • Identifying specific chromosomal changes associated with different tumor sites and conditions can inform targeted therapies.
    • The findings underscore the importance of considering tumor heterogeneity and evolution in personalized cancer treatment approaches.