Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic predisposition to two rheumatic diseases.

P L Tan, D E Caughey, M F Jagusch

    The New Zealand Medical Journal
    |June 8, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Material radiopurity control in the XENONnT experiment.

    The European physical journal. C, Particles and fields·2022
    Same author

    Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability.

    Nature communications·2017
    Same author

    Timing of antenatal steroids exposure and its effects on neonates.

    Archives of gynecology and obstetrics·2017
    Same author

    A single-center experience of cytomegalovirus infections in Asian pediatric patients undergoing allogeneic hematopoietic stem cell transplant for leukemia in Singapore.

    Transplant infectious disease : an official journal of the Transplantation Society·2014
    Same author

    Severe Kikuchi's disease responsive to immune modulation.

    Singapore medical journal·2010
    Same author

    Streptococcal cellulitis following preparation of fresh raw seafood.

    Zoonoses and public health·2009

    Ankylosing spondylitis and rheumatoid arthritis co-existence is rare, often seen in males. This case highlights the association with specific human leukocyte antigen (HLA) genes.

    Area of Science:

    • Rheumatology
    • Immunogenetics

    Background:

    • Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are distinct inflammatory arthropathies.
    • Their co-existence is clinically uncommon, presenting diagnostic challenges.

    Observation:

    • The patient presented with a history suggestive of ankylosing spondylitis followed by rheumatoid arthritis features.
    • This dual diagnosis occurred in the third or fourth decade of life, typical for RA onset.

    Findings:

    • The patient possessed human leukocyte antigen (HLA) genes associated with both ankylosing spondylitis and rheumatoid arthritis.
    • This finding supports a genetic predisposition to the co-occurrence of these conditions.

    Implications:

    • Understanding the genetic basis, particularly HLA associations, can improve diagnosis and management of co-existing AS and RA.

    Related Experiment Videos

  • Further research into shared genetic factors may reveal novel therapeutic targets for these autoimmune diseases.