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Early events in the suppression of myeloid leukemic cells by biological regulators
Haematology and Blood Transfusion
|January 1, 1983
Abstract:
Differentiation of mouse and human myeloid leukemic cells in vitro can be induced by some members of the granulocytemacrophage family of colony-stimulating factors. In the mouse, the most active molecule (G-CSF) is able to suppress leukemic stem cell self-generation in an irreversible, asymmetric process, suggesting that the factor permanently modifies newly synthesized one or more daughter chromatids in dividing leukemic stem cells.