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Related Experiment Videos

Plasma acetate levels during hemodialysis.

G Desch, R Oules, C Mion

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |May 2, 1978
    PubMed
    Summary

    Patients undergoing hemodialysis show varied acetate metabolism during treatment, with some reaching a plateau and others experiencing continuous rises. Acetate levels rapidly decrease post-dialysis, indicating efficient turnover.

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    Area of Science:

    • Nephrology
    • Biochemistry

    Background:

    • Elevated acetate levels can occur in patients with chronic renal failure.
    • Acetate is commonly used as a buffer in hemodialysis fluid.

    Purpose of the Study:

    • To investigate acetate kinetics and metabolism during hemodialysis in patients with chronic renal failure.
    • To understand the variability in acetate handling among hemodialysis patients.

    Main Methods:

    • Measurement of plasma acetate concentrations before, during, and after hemodialysis.
    • Calculation of acetate mass transfer from the blood compartment using plasma flow and concentrations.
    • Comparison of acetate levels and kinetics between hemodialyzed patients and normal subjects.

    Main Results:

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  • Hemodialyzed patients exhibited wider pre-dialysis plasma acetate ranges and higher mean values compared to normal subjects.
  • Significant individual variability in acetate kinetics was observed during hemodialysis, with some patients reaching a plateau and others showing continuous increases in plasma acetate.
  • Acetate mass transfer rates ranged from 2.4 to 4.1 mmol/min.
  • A rapid decline in arterial acetate concentrations was noted within 20 minutes post-dialysis.

    • Conclusions:

    • Patients with chronic renal failure demonstrate considerable individual differences in acetate metabolism during hemodialysis.
    • The rapid post-dialysis acetate clearance suggests efficient acetate turnover in humans.
    • Further research is warranted to elucidate the factors contributing to acetate metabolism variability in hemodialysis patients.