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Related Experiment Videos

Trichosporon hepatitis.

J K Korinek, L A Guarda, R Bolivar

    Gastroenterology
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    A rare fungal infection, Trichosporon cutaneum, caused liver disease in a leukemia patient undergoing chemotherapy. Despite treatment, the infection led to fatal fungemia and sepsis.

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    Area of Science:

    • Medical Mycology
    • Hematology
    • Hepatology

    Background:

    • A 33-year-old woman with relapsed acute myelomonocytic leukemia received chemotherapy and antibiotics.
    • She was being treated with amphotericin for a suspected Aspergillus infection.

    Observation:

    • The patient developed hepatomegaly, elevated liver enzymes, and high serum bilirubin.
    • Liver biopsy revealed granulomatous fungal hepatitis caused by Trichosporon cutaneum.

    Findings:

    • Despite amphotericin and 5-fluorocytosine treatment, Trichosporon was isolated from blood cultures.
    • The patient ultimately died from fungemia and polymicrobial sepsis.

    Implications:

    • This case highlights the risk of opportunistic fungal infections, such as Trichosporon cutaneum, in immunocompromised patients.
  • It underscores the challenges in treating invasive fungal infections in leukemia patients, even with combination antifungal therapy.