A model of immunologic unresponsiveness and its relevance to autoimmunity

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Immunology today·2014

The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling.

Pathologie-biologie·2003

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.

Nature immunology·2001

Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice.

European journal of immunology·2001

An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major.

Journal of immunology (Baltimore, Md. : 1950)·2000

In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease.

Journal of immunology (Baltimore, Md. : 1950)·2000

Bone marrow transplantation: current status.

Pathobiology annual·1982

Biology of cardiac overload.

Pathobiology annual·1982

Parathyroid hormone: chemistry and structure-activity relations.

Pathobiology annual·1981

Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides.

Pathobiology annual·1981

Endobronchial lipoma presenting as a fat-attenuation lesion causing left upper lobar bronchial obstruction: A case report.

Radiology case reports·2026

Immunomodulation of microglia/macrophages and neutrophils as immunotherapeutic targets in ischemic stroke: A narrative review.

Brain circulation·2026

Kidney Allograft Outcomes in Borderline and T Cell-Mediated Rejection With Microvascular Inflammation.

Kidney international reports·2026

Overlap Myositis in a Patient With Psoriasis Treated With Anti-TNF-Alpha Therapy: A Case Report and Review of Literature.

Case reports in rheumatology·2026

Case Report: From idiopathic recurrent pericarditis to systemic Behçet's Disease: unmasking a unified IL-1-driven autoinflammatory phenotype.

Frontiers in immunology·2026

Lower invasiveness of papillary thyroid carcinoma associated with Hashimoto's thyroiditis: evidence from AJCC 8th-edition stratification and a dose-response relationship with autoantibody titers.

Frontiers in endocrinology·2026

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A model of immunologic unresponsiveness and its relevance to autoimmunity

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Making the immune system work.

The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling.

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.

Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice.

An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major.

In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease.

Bone marrow transplantation: current status.

Biology of cardiac overload.

Parathyroid hormone: chemistry and structure-activity relations.

Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides.

Endobronchial lipoma presenting as a fat-attenuation lesion causing left upper lobar bronchial obstruction: A case report.

Immunomodulation of microglia/macrophages and neutrophils as immunotherapeutic targets in ischemic stroke: A narrative review.

Kidney Allograft Outcomes in Borderline and T Cell-Mediated Rejection With Microvascular Inflammation.

Overlap Myositis in a Patient With Psoriasis Treated With Anti-TNF-Alpha Therapy: A Case Report and Review of Literature.

Case Report: From idiopathic recurrent pericarditis to systemic Behçet's Disease: unmasking a unified IL-1-driven autoinflammatory phenotype.

Lower invasiveness of papillary thyroid carcinoma associated with Hashimoto's thyroiditis: evidence from AJCC 8th-edition stratification and a dose-response relationship with autoantibody titers.

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A model of immunologic unresponsiveness and its relevance to autoimmunity

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