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Urea-prostaglandin versus hypertonic saline for instillation abortion
American Journal of Obstetrics and Gynecology
|August 15, 1983
Summary
A combination of urea and prostaglandin F2 alpha is a safer and faster second-trimester abortion method than hypertonic saline solution. This urea-prostaglandin treatment demonstrated fewer serious complications and a shorter induction-to-abortion time.
Area of Science:
- Reproductive Medicine
- Pharmacology
Background:
- Hypertonic saline solution has been used for second-trimester abortions.
- Disadvantages associated with hypertonic saline solution have prompted investigation into alternative methods.
Purpose of the Study:
- To compare the safety and efficacy of urea-prostaglandin combination therapy with hypertonic saline solution for second-trimester intra-amniotic abortion.
Main Methods:
- Prospective multicenter study conducted in the United States between 1975 and 1978.
- Analysis of data comparing urea-prostaglandin instillation versus saline solution instillation.
Main Results:
- Both urea-prostaglandin and saline solution were highly effective in inducing abortion.
- Urea-prostaglandin showed a significantly lower rate of serious complications (1.03 per 100 abortions) compared to saline solution (2.18 per 100 abortions).
- The induction-to-abortion time was significantly shorter with urea-prostaglandin (14.2 hours) than with saline solution (25.6 hours).
Conclusions:
- Urea-prostaglandin appears to be a superior abortifacient agent compared to hypertonic saline solution for second-trimester abortions.
- The combination therapy offers improved safety and efficiency.
Keywords:
Abortifacient AgentsAbortion HistoryAbortion, Drug InducedAbortion, InducedAge FactorsBiologyBleedingCervical EffectsEndocrine SystemEndometritisEthnic GroupsEvaluationFamily PlanningFertility Control, PostconceptionIngredients And ChemicalsLaminaria TentsMarital StatusOrganic Chemicals--administraction and dosageOrganic Chemicals--complicationsPhysiologyPregnancy HistoryProstaglandins--administraction and dosageProstaglandins--complicationsSaline Solution, Hypertonic--administraction and dosageSaline Solution, Hypertonic--complicationsSurgery