Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monocusp aortic valve replacement in dogs: an experimental model.

J Goldstein, M C Robinson, G R McDonald

    The Australian and New Zealand Journal of Surgery
    |April 1, 1983
    PubMed
    Summary

    Human allograft valves are used in aortic valve replacement, showing host-graft interactions. Sterilizing agents affect these interactions, studied using a novel canine model for tissue ingrowth patterns.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Use of an Animal Lung as Oxygenator in a Heart-Lung Machine.

    The Medical journal of the South-West·2017
    Same author

    Working with workers' compensation: one lawyer's opinion.

    Journal of back and musculoskeletal rehabilitation·2014
    Same author

    Initial Experiences with Extracorporeal Circulation in Intracardiac Surgery.

    British medical journal·2010
    Same author

    Surgical treatment of congenital heart disease at Green Lane Hospital: an historical review.

    The New Zealand medical journal·2001
    Same author

    Early experience with the mosaic bioprosthesis: a new generation porcine valve.

    The Annals of thoracic surgery·2000
    Same author

    The medtronic intact porcine valve: ten-year clinical review.

    The Journal of thoracic and cardiovascular surgery·1998

    Area of Science:

    • Cardiovascular Surgery
    • Tissue Engineering
    • Immunology

    Background:

    • Aortic valve replacement with human allografts is a standard procedure.
    • Histological analysis reveals host-graft interactions post-implantation.
    • The intensity of these interactions is influenced by graft processing agents.

    Purpose of the Study:

    • To investigate host-graft interactions in aortic allografts.
    • To evaluate the impact of sterilizing and storage agents on allograft tissue ingrowth.
    • To introduce a canine experimental model for studying these phenomena.

    Main Methods:

    • Development of a canine experimental model.
    • Detailed description of the surgical technique for allograft implantation in canines.

    Related Experiment Videos

  • Analysis of tissue ingrowth patterns in allografts treated with different agents.

    • Main Results:

    • Histological evidence of host-graft interaction is consistently observed.
    • Variability in interaction intensity correlates with specific sterilizing and storage agents.
    • The canine model successfully demonstrates differential tissue ingrowth patterns.

    Conclusions:

    • The canine model provides a viable platform for studying aortic allograft-host interactions.
    • Graft processing significantly impacts the biological response to allografts.
    • Further research can optimize allograft treatment protocols based on these findings.