Intranuclear vermicellar bodies in human osteosarcoma and ossifying fibroma cells

Electron microscopic investigation of 16 cases of human bone tumor revealed the presence of intranuclear vermicellar bodies (IVB) in cells of two osteosarcomas and one ossifying fibroma. The spherical nuclear inclusions consisted of electron-dense, interwoven, threadlike structures measuring approximately 20-30 nm in diameter. The nature and significance of the IVB remain obscure at present.