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Effect of cimetidine on renal function in normal man.
Clinical Pharmacology and Therapeutics
|July 1, 1978
Summary
Histamine H2-receptor blockade with cimetidine did not significantly alter renal function, including acid excretion, bicarbonate reabsorption, or concentrating ability. Creatinine clearance decreased during bicarbonate infusion, suggesting potential tubular secretion effects.
Area of Science:
- Nephrology
- Pharmacology
- Physiology
Background:
- Histamine H2-receptor antagonists are widely used.
- Their effects on renal function require detailed investigation.
- Cimetidine is a common H2-receptor antagonist.
Purpose of the Study:
- To assess the impact of acute histamine H2-receptor blockade on key renal functions.
- To determine if cimetidine affects acid excretion, bicarbonate handling, or urinary concentration.
- To investigate potential changes in renal clearance parameters.
Main Methods:
- Renal function studies were conducted in a control state and after cimetidine administration.
- Evaluated acid excretion during acid loading.
- Assessed bicarbonate reabsorption during bicarbonate infusion.
- Measured urinary concentrating ability.
Main Results:
- Cimetidine administration showed no significant effect on acid excretion or urinary concentrating ability.
- Bicarbonate reabsorption remained unaffected by cimetidine.
- During bicarbonate infusion, inulin clearance was constant, but creatinine clearance decreased.
- The fall in creatinine clearance may be attributed to altered tubular creatinine secretion.
Conclusions:
- Acute histamine H2-receptor blockade with cimetidine does not significantly impair major renal functions.
- A potential effect on tubular creatinine secretion warrants further investigation.
- Cimetidine appears safe concerning basic renal physiological processes.