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Familial occurrence in carcinoid tumours.
The Australian and New Zealand Journal of Surgery
|August 1, 1983
Summary
Familial carcinoid tumors, distinct from multiple endocrine neoplasia (MEN) syndrome, were identified in two new family groups. Genetic screening of relatives with gastrointestinal symptoms is recommended for early detection.
Area of Science:
- Oncology
- Genetics
- Endocrinology
Background:
- Carcinoid tumors are neuroendocrine neoplasms.
- Familial occurrence of carcinoid tumors is rare.
- Multiple Endocrine Neoplasia (MEN) syndromes can include carcinoid tumors.
Observation:
- Presents two new family groups with familial carcinoid tumors and metastases.
- These cases are not associated with MEN syndromes.
- Represents the fourth and fifth reported family groups with non-MEN familial carcinoid tumors.
Findings:
- Identified familial carcinoid tumors in two distinct family groups.
- Confirmed the absence of MEN syndrome in these familial cases.
- Highlights the existence of familial carcinoid tumors independent of MEN syndromes.
Implications:
- Suggests a genetic predisposition to carcinoid tumors outside of MEN syndromes.
- Recommends investigation of relatives of carcinoid tumor patients with persistent gastrointestinal symptoms.
- Emphasizes the importance of considering non-MEN familial carcinoid tumors in differential diagnosis.