Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polynesian bronchiectasis.

D A Waite, S J Wakefield, K M Moriarty

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The potential for over diagnosis of Paget's disease of bone using macroscopic analysis.

    International journal of paleopathology·2022
    Same author

    V3-Loop genotypes do not predict maraviroc susceptibility of CCR5-tropic virus or clinical response through week 48 in HIV-1-infected, treatment-experienced persons receiving optimized background regimens.

    Antiviral chemistry & chemotherapy·2021
    Same author

    Highly prevalent Russian HIV-1 V3-loop sequence variants are susceptible to maraviroc.

    Antiviral chemistry & chemotherapy·2021
    Same author

    Social Network Organization, Structure, and Patterns of Influence Within a Community of Transgender Women in Lima, Peru: Implications for Biomedical HIV Prevention.

    AIDS and behavior·2019
    Same author

    The influence of chronic conditions and the environment on pubertal development. An example from medieval England.

    International journal of paleopathology·2018
    Same author

    Neutrophils, oxidative killing mechanisms and chemiluminescence.

    New Zealand veterinary journal·2016

    Polynesian children with recurrent respiratory infections and abnormal mucociliary clearance showed no signs of immunodeficiency. Further research is needed to understand their specific lung condition.

    Area of Science:

    • Pediatrics
    • Immunology
    • Respiratory Medicine

    Background:

    • Recurrent lower respiratory infections and abnormal lung mucociliary clearance are significant health concerns in Polynesian children.
    • The underlying causes of these conditions, including potential immunodeficiency, require thorough investigation.

    Purpose of the Study:

    • To assess Polynesian children with recurrent lower respiratory infections and abnormal mucociliary clearance for underlying immunodeficiency.
    • To evaluate immune status, including immunoglobulins, complement components, and cellular immunity, in affected children.

    Main Methods:

    • Serum immunoglobulin (IgG, IgM, IgA) and complement (C3, C4) levels were measured.
    • Leukocyte function tests and T and B cell populations were analyzed.
    • Sputum secretory-IgA was assessed in bronchiectatic patients, and nasal epithelium ultrastructure was examined in affected children.

    Related Experiment Videos

    Main Results:

    • No evidence of immunodeficiency was found in the assessed Polynesian children.
    • Sputum secretory-IgA levels were normal, with four children exhibiting high levels.
    • Nasal ciliated epithelium was obtained in 4 out of 6 children, with normal ultrastructure observed in the limited samples.

    Conclusions:

    • The study found no evidence of immunodeficiency contributing to recurrent respiratory infections and abnormal mucociliary clearance in these Polynesian children.
    • The findings suggest that the observed respiratory issues may stem from factors other than primary immunodeficiency.
    • Further investigation into the specific mechanisms of mucociliary dysfunction in this population is warranted.