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Histamine receptors in the bronchi.

N M Eiser

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1983
    PubMed
    Summary

    Histamine primarily causes bronchoconstriction in humans via H1-receptors, especially in asthmatics. H1-receptor antagonists effectively treat asthma symptoms and prevent bronchospasm.

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    Area of Science:

    • Pulmonary Medicine
    • Pharmacology
    • Allergy and Immunology

    Background:

    • Histamine's effects on airways vary significantly across species and locations.
    • Histamine receptor distribution likely explains these inter-species and intra-airway variations.

    Purpose of the Study:

    • To investigate the role of histamine receptors in human airway function, particularly in asthma.
    • To determine the efficacy of H1-receptor antagonists in managing histamine-induced bronchospasm and asthma symptoms.

    Main Methods:

    • Review of existing literature on histamine receptor distribution and function in human airways.
    • Analysis of clinical data on the effects of H1-receptor antagonists in normal and asthmatic subjects.

    Main Results:

    • H1-receptors predominate in human airways, mediating potent bronchoconstriction, especially in asthmatics.
    • H1-receptor antagonists effectively relieve bronchial tone, prevent histamine-induced bronchospasm, and partially mitigate antigen- and exercise-induced asthma.
    • Evidence for H2-receptors in human airways is contradictory, with a likely trivial role if present.

    Conclusions:

    • Histamine acts as a significant bronchoconstrictor in humans, primarily through H1-receptors.
    • H1-receptor antagonists represent a viable therapeutic strategy for managing asthma and related bronchoconstrictive conditions.
    • No significant differences in histamine receptor patterns were observed between normal and asthmatic individuals.

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