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Related Experiment Videos

Changes of mucociliary function during colds.

Y Sakakura

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Acute upper respiratory infections impair mucociliary function, increasing nasal transit time. Recovery involves mucosal repair, but ciliary damage and mucus tethering can persist, affecting transport during common colds.

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    Area of Science:

    • Immunology
    • Virology
    • Respiratory Medicine

    Background:

    • Mucociliary function is crucial for clearing the respiratory tract.
    • Acute upper respiratory infections can compromise this defense mechanism.

    Purpose of the Study:

    • To investigate the relationship between mucociliary function and acute upper respiratory infection using a chicken model.
    • To understand the impact of viral infection on nasal transit time and the underlying pathological changes.

    Main Methods:

    • Utilized chickens infected with Newcastle disease virus.
    • Measured nasal transit time of dye.
    • Performed histopathological studies and scanning electron microscopy.
    • Employed 3H-thymidine autoradiography for repair assessment.

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  • Analyzed nasal secretions on a frog palate model.

    • Main Results:

    • Infected chickens showed significantly longer nasal transit times.
    • Mucosal injury repair was observed within 13 days, but ciliary damage persisted.
    • Mucus tethering to the mucosal surface increased with infection duration.
    • Nasal secretions from common cold patients exhibited slower transport rates.

    Conclusions:

    • Acute viral infections disrupt mucociliary transport through ciliary damage and altered mucus properties.
    • Mucus tethering is a potential in vivo factor affecting transport.
    • Reduced mucociliary transport during common colds results from combined pathological effects.