Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pseudoxanthoma elasticum.

M W Engelman, M T Fliegelman

    Cutis
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Pseudoxanthoma elasticum (PXE) is a rare genetic disorder affecting connective tissue. This review covers its clinical, pathological, and genetic aspects, alongside current and emerging therapeutic strategies for this multi-systemic condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Macrodactyly and epidermal nevus.

    Cutis·1977
    Same author

    Cutaneous immunofluorescence in systemic disease.

    The Journal of the Kentucky Medical Association·1977
    Same author

    Scleredema of Buschke.

    International journal of dermatology·1976
    Same author

    Ultrastructural study of a case of angiolymphoid hyperplasia with eosinophilia.

    Archives of dermatology·1974
    Same author

    Seasonal variation of basal cell epitheliomas in Kentucky.

    Archives of dermatology·1974
    Same author

    Molluscum contagiosum occurring in epidermal inclusion cysts.

    Archives of dermatology·1973

    Area of Science:

    • Genetics and rare diseases
    • Connective tissue disorders
    • Medical pathology

    Background:

    • Pseudoxanthoma elasticum (PXE) is a genetic disorder impacting connective tissue.
    • It presents with multi-systemic manifestations, notably affecting skin, eyes, and the cardiovascular system.
    • While skin changes are visible, ocular and cardiovascular complications pose the most severe risks to patients.

    Purpose of the Study:

    • To provide a comprehensive review of Pseudoxanthoma elasticum (PXE).
    • To discuss current clinical and pathological findings.
    • To explore recent advancements in therapeutic approaches, pathogenesis, and genetics.

    Main Methods:

    • Literature review of clinical and pathological findings in PXE.
    • Analysis of recent research on PXE pathogenesis and genetics.

    Related Experiment Videos

  • Summary of current and emerging therapeutic strategies for PXE.

    • Main Results:

    • PXE is characterized by progressive calcification and fragmentation of elastic fibers.
    • Ocular manifestations include angioid streaks, leading to potential vision loss.
    • Cardiovascular involvement can result in peripheral arterial disease and hypertension.

    Conclusions:

    • PXE requires a multi-disciplinary approach for management due to its systemic nature.
    • Understanding the genetic basis of PXE is crucial for developing targeted therapies.
    • Ongoing research into pathogenesis and therapeutics offers hope for improved patient outcomes.