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Changes with aging in serum lipoproteins and apolipoprotein C subclasses
Archives of Gerontology and Geriatrics
|July 1, 1983
Summary
Serum lipid and lipoprotein levels change with age in men, with highest levels in the 6th-7th decades. Lecithin:cholesterol acyltransferase (LCAT) activity declines, but lipoprotein lipase activity may remain unimpaired.
Area of Science:
- Gerontology
- Lipid Metabolism
- Cardiovascular Health
Background:
- Aging significantly impacts physiological processes, including lipid metabolism.
- Understanding age-related changes in lipoproteins is crucial for cardiovascular health.
- Previous research indicates alterations in lipid profiles with advancing age.
Purpose of the Study:
- To investigate the effects of aging on serum lipids, lipoproteins, and apolipoprotein C subclasses in very low-density lipoprotein (VLDL).
- To analyze age-related trends in cholesterol, triglycerides, and specific lipoprotein fractions in healthy males across nine decades.
Main Methods:
- Analysis of serum lipids, phospholipids, and triglycerides.
- Immunological determination of beta-lipoprotein concentration.
- Electrophoretic analysis of beta-lipoprotein percentage.
- Measurement of VLDL, LDL, and HDL cholesterol levels.
- Quantification of apolipoprotein A and C subclasses in VLDL.
Main Results:
- Serum cholesterol, phospholipid, and triglyceride levels peaked in the 6th-7th decades.
- VLDL-LDL cholesterol levels paralleled total cholesterol changes.
- HDL cholesterol and apolipoprotein A remained stable with age.
- Free cholesterol and apolipoprotein content in LDL increased with age.
- The apo C II/C III ratio in VLDL increased with age.
Conclusions:
- Aging leads to significant alterations in serum lipid and lipoprotein profiles in men.
- Lecithin:cholesterol acyltransferase (LCAT) activity appears to decline with age.
- Lipoprotein lipase activity may not be impaired by the aging process.